After 11 weeks of eating to get proper nutrition I have observed the following changes in my blood sugar.
1. My weekly average fasting blood sugar is approximately 40 points lower than when I started.
2. I have eliminated Actos from my treatment regime.
3. When I eliminated Actos (which wasn't done as cleanly as I'd like) I saw roughly a 20 point rise in blood sugar
4. Presumably if I was still on Actos my blood sugars would be 20 points lower still, representing a 60 point drop. I'll concede this is totally inferred and is not based on actual data.
5. It appears my new diet (what I'm eating, not how little I eat - the noun, not the verb) is resulting in an average 5-6 point drop in blood sugar per week.
6. I have lost 28 pounds and my blood pressure has dropped to 132/62 (nominally) and I've reduced my medicine by 75%.
7. The effect on lipid chemistry is entirely unknown but I'm guessing the report I'll get at the end of the month will be good. Again, no data, just my opinion.
Looking forward I've done some modest research on the effect of metformin on blood sugar. One study looked at patients taking 500 mg, 1000 mg, 1500 mg, and 2000 mg of metformin daily. It found the reduction in serum blood sugar varied from 19 mg/dl to 82mg/dl, respectively. It also found that there was a correlation between BMI and the effect of metformin. The reduction in blood sugar was noted in people who were over-weight (BMI 25 or more) and obese (BMI 30 or more). No effect was notice in people with a BMI <25 (i.e., normal weight).
So, I'll discuss my plan with my doctor but the concept is this. When my weekly average fasting blood sugar approaches 110 mg/dl I'll drop my metformin dosage by 500 mg. That should keep my blood sugars in a safe range. I'm currently taking 2,000 mg of metformin daily; 1,000 mg morning and again in the evening. I'll cut the evening dose first because the time to the next dose is short - frankly, I don't think it will matter. I expect I'll start reducing metformin in 3-4 weeks, assuming my blood sugars continue to drop. I also expect to be able to make additional cuts in metformin every 3-4 weeks.
Looking ahead, I think I will be off blood pressure medicine entirely in the next few months (maybe sooner). Unless my rate of change in fasting blood sugar averages changes (and it could speed up or slow down), I think I'll be off metformin (my last blood sugar drug) in September or October. One reason I am considering the possibility of the rate of change increasing, is I have read where fasting can cause biochemical changes in how glucose is produced and metabolized. It appears fasting for 2 days (or more) can improve insulin response significantly. A 2 day fast would be interesting both biologically and religiously, and I think that's worth pondering.
No comments:
Post a Comment